| RANK | CITY | STATE | COUNTRY | REGION | 2010 GRADE |
| 1 | Boston | Massachusetts | United States | AMERICAS | 1 NEXUS |
| 2 | Paris | France | EUROPE | 1 NEXUS | |
| 3 | Amsterdam | Netherlands | EUROPE | 1 NEXUS | |
| 4 | Vienna | Austria | EUROPE | 1 NEXUS | |
| 5 | New York | New York | United States | AMERICAS | 1 NEXUS |
| 6 | Frankfurt | Germany | EUROPE | 1 NEXUS | |
| 7 | San Francisco | California | United States | AMERICAS | 1 NEXUS |
| 8 | Copenhagen | Denmark | EUROPE | 1 NEXUS | |
| 9 | Lyon | France | EUROPE | 1 NEXUS | |
| 10 | Hamburg | Germany | EUROPE | 1 NEXUS | |
| 11 | Berlin | Germany | EUROPE | 1 NEXUS | |
| 12 | Toronto | Canada | AMERICAS | 1 NEXUS | |
| 13 | Stuttgart | Germany | EUROPE | 1 NEXUS | |
| 14 | London | United Kingdom | EUROPE | 1 NEXUS | |
| 15 | Munich | Germany | EUROPE | 1 NEXUS | |
| 16 | Milan | Italy | EUROPE | 1 NEXUS | |
| 17 | Stockholm | Sweden | EUROPE | 1 NEXUS | |
| 18 | Hong Kong | Hong Kong | Hong Kong | ASIA | 1 NEXUS |
| 19 | Melbourne | VIC | Australia | ASIA | 1 NEXUS |
| 20 | Tokyo | Tokyo | Japan | ASIA | 1 NEXUS |
| 21 | Rome | Italy | EUROPE | 1 NEXUS | |
| 22 | Kyoto | Kyoto | Japan | ASIA | 1 NEXUS |
| 23 | Washington DC | District of Columbia | United States | AMERICAS | 1 NEXUS |
| 24 | Shanghai | Shanghai | China | ASIA | 1 NEXUS |
| 25 | Düsseldorf | Germany | EUROPE | 1 NEXUS | |
| 26 | Barcelona | Spain | EUROPE | 1 NEXUS | |
| 27 | Seoul | Korea, South | ASIA | 1 NEXUS | |
| 28 | Sydney | NSW | Australia | ASIA | 1 NEXUS |
| 29 | Prague | Czech Republic | EUROPE | 1 NEXUS | |
| 30 | Philadelphia | Pennsylvania | United States | AMERICAS | 1 NEXUS |
| 31 | Singapore | Singapore | ASIA | 2 HUB | |
| 32 | Brussels | Belgium | EUROPE | 2 HUB | |
| 33 | Strasbourg | France | EUROPE | 2 HUB | |
| 34 | Montréal | Canada | AMERICAS | 2 HUB | |
| 35 | Seattle | Washington | United States | AMERICAS | 2 HUB |
| 36 | Nantes | France | EUROPE | 2 HUB | |
| 37 | Helsinki | Finland | EUROPE | 2 HUB | |
| 38 | Marseille | France | EUROPE | 2 HUB | |
| 39 | Leipzig | Germany | EUROPE | 2 HUB | |
| 40 | Cologne | Germany | EUROPE | 2 HUB | |
| 41 | Toulouse | France | EUROPE | 2 HUB | |
| 42 | Karlsruhe | Germany | EUROPE | 2 HUB | |
| 43 | Bordeaux | France | EUROPE | 2 HUB | |
| 44 | Austin | Texas | United States | AMERICAS | 2 HUB |
| 45 | Minneapolis-St Paul | Minnesota | United States | AMERICAS | 2 HUB |
| 46 | Oslo | Norway | EUROPE | 2 HUB | |
| 47 | Chicago | Illinois | United States | AMERICAS | 2 HUB |
| 48 | Wellington | New Zealand | ASIA | 2 HUB | |
| 49 | Dresden | Germany | EUROPE | 2 HUB | |
| 50 | Tel Aviv | Israel | EUROPE | 2 HUB | |
| 51 | Auckland | New Zealand | ASIA | 2 HUB | |
| 52 | Fukoaka | Fukoaka | Japan | ASIA | 2 HUB |
| 53 | Beijing | Beijing | China | ASIA | 2 HUB |
| 54 | Geneva | Switzerland | EUROPE | 2 HUB | |
| 55 | The Hague | Netherlands | EUROPE | 2 HUB | |
| 56 | Abu Dhabi | United Arab Emirates | EMERGING | 2 HUB | |
| 57 | Montpellier | France | EUROPE | 2 HUB | |
| 58 | Manchester | United Kingdom | EUROPE | 2 HUB | |
| 59 | Zürich | Switzerland | EUROPE | 2 HUB | |
| 60 | Madrid | Spain | EUROPE | 2 HUB | |
| 61 | Budapest | Hungary | EUROPE | 2 HUB | |
| 62 | Nuremberg | Germany | EUROPE | 2 HUB | |
| 63 | Ann Arbor | Michigan | United States | AMERICAS | 2 HUB |
| 64 | Edinburgh | United Kingdom | EUROPE | 2 HUB | |
| 65 | Bonn | Germany | EUROPE | 2 HUB | |
| 66 | Aachen | Germany | EUROPE | 2 HUB | |
| 67 | Essen | Germany | EUROPE | 2 HUB | |
| 68 | Glasgow | United Kingdom | EUROPE | 2 HUB | |
| 69 | Los Angeles | California | United States | AMERICAS | 2 HUB |
| 70 | Rotterdam | Netherlands | EUROPE | 2 HUB | |
| 71 | Calgary | Alberta | Canada | AMERICAS | 2 HUB |
| 72 | Raleigh-Durham | North Carolina | United States | AMERICAS | 2 HUB |
| 73 | Dortmund | Germany | EUROPE | 2 HUB | |
| 74 | Québec | Canada | AMERICAS | 2 HUB | |
| 75 | Vancouver | Canada | AMERICAS | 2 HUB | |
| 76 | Basel | Switzerland | EUROPE | 2 HUB | |
| 77 | Reims | France | EUROPE | 2 HUB | |
| 78 | Springfield | Massachusetts | United States | AMERICAS | 2 HUB |
| 79 | Pittsburgh | Pennsylvania | United States | AMERICAS | 2 HUB |
| 80 | Linz | Austria | EUROPE | 2 HUB | |
| 81 | Torino | Italy | EUROPE | 2 HUB | |
| 82 | Portland | Oregon | United States | AMERICAS | 2 HUB |
| 83 | Antwerp | Belgium | EUROPE | 2 HUB | |
| 84 | St Petersburg | Russia | EUROPE | 2 HUB | |
| 85 | Hannover | Germany | EUROPE | 2 HUB | |
| 86 | Nice | France | EUROPE | 2 HUB | |
| 87 | Dallas-Fort Worth | Texas | United States | AMERICAS | 2 HUB |
| 88 | Kobe | Hyogo | Japan | ASIA | 2 HUB |
| 89 | Venice | Italy | EUROPE | 2 HUB | |
| 90 | Denver | Colorado | United States | AMERICAS | 2 HUB |
| 91 | Kiel | Germany | EUROPE | 2 HUB | |
| 92 | Baltimore | Maryland | United States | AMERICAS | 2 HUB |
| 93 | Osaka | Osaka | Japan | ASIA | 2 HUB |
| 94 | São Paulo | Brazil | AMERICAS | 2 HUB | |
| 95 | Edmonton | Canada | AMERICAS | 2 HUB | |
| 96 | Belgrade | Serbia | EUROPE | 3 NODE | |
| 97 | Moscow | Russia | EUROPE | 3 NODE | |
| 98 | Buenos Aires | Argentina | AMERICAS | 3 NODE | |
| 99 | Dubai | United Arab Emirates | EMERGING | 3 NODE | |
| 100 | Atlanta | Georgia | United States | AMERICAS | 3 NODE |
Key to index.
All cities are graded into award categories based on their index score. In descending order of importance to the innovation economy:NEXUS: Critical nexus for innovation across economic and social segments
HUB: Dominance or influence on key economic and social segments given current trends
NODE: Broad performance across many segments, some imbalances
INFLUENCER: Competitive in some segments, imbalanced
UPSTART: Potential steps towards future performance in a few segments (new in 2010)
Regions are defined as follows:AMERICAS: North and South America
EUROPE: The U.N. defined Europe with European union, Western Russia, Israel and Turkish cities
ASIA: Asia and Oceania (Australia/NZ)
EMERGING: Mid-East, Africa and Caucasus states
WSOP & SCOOP FTOPS
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